SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity

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Yale SARS-CoV-2 Genomic Surveillance Initiative

In collaboration with public health agencies and diagnostic labs across Connecticut, we established a routine SARS-CoV-2 genomic surveillance system to track emerging variants.

Genomic epidemiology to track SARS-CoV-2

Back to our regular programing…

Yale School of Public Health

The Grubaugh Lab is located within the Yale School of Public Health, Department of Epidemiology of Microbial Diseases. Our department uniquely combines clinical, computational, and laboratory-based approaches to combat infectious diseases around the world.

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Genomics to study virus emergence

We are using pathogen genomics to study how mosquito- and tick-borne viruses, like Zika, West Nile, chikungunya, and Powassan emerge into new areas, cause disease, and adapt to novel environments. Ultimately, our goal is to better understand and respond to outbreaks.

learn more about our research

Novel methods to detect oubreaks

WestNile 4K Project

By partnering with Kristian Andersen, Ryan Smith, and 40+ surveillance labs from across the country, we are planning to sequence more than 4,000 virus genomes to reconstruct a high definition picture of West Nile virus spread and evolution during the last 20 years in the United States. The data that we generate will be immediately released and, along with other entomological data, will be used to uncover local transmission dynamics. 

see our progress

Rapid data sharing using Nextstrain

Nextstrain is an open-source project created by Trevor Bedford and Richer Neher to harness the scientific and public health potential of pathogen genome data. We recently teamed up with the Nextstrain team, including James Hadfield, to create a portal to visualize West Nile virus spread and evolution during the last 20 years in North America. We also create “community” pages to share ongoing data analysis with our collaborators and the public.

see Nextstrain in action
Want to join the fun?

We are always looking for talented scientists to join the group.

Job posting
Open science

We’ll make our data and protocols available as they are generated.

data and protocols
If you like the art…

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steampunk phage

The latest from New Haven…

We’re hiring postdocs

Updated September 28, 2022 Postdoc / Associate Research Scientist position in biostats / modeling to study SARS-CoV-2 variants The Yale School of Public Health (YSPH) is seeking a Postdoc or[…]

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Teaming up with the NBA

In June 2020, we formed a collaboration with the National Basketball Association (NBA) and the Players Association (NBPA) to develop a new saliva-based SARS-CoV-2 test (SalivaDirect) and to uncover key[…]

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Tracking COVID-19 outbreaks in the NFL

An interview with Joseph Fauver by the Wall Street Journal outlines how we used genomic sequencing to track the spread of SARS-CoV-2 in NFL facilities. Article: Decoding an Outbreak: How[…]

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